The known influence of these PTMs on ATXN2’s operate and SCA2 pathogenesis stays constrained. In other polyQ diseases, multiple research advised that proteolytic cleavage of polyQ proteins could play an important function in pathogenesis [36, forty five]. Aligned with this particular concept, the existence of the enriched 42 kDa fragment during https://eddieu099fqa1.jasperwiki.com/user