The neurologic phenotype in SCA8 BAC expansion but not BAC Command lines demonstrated the pathogenicity with the (CTG-CAG)n enlargement. Moreover, the expression of noncoding (CUG)n expansion ATXN8OS transcripts and the discovery of intranuclear polyglutamine inclusions proposed that SCA8 pathogenesis entails toxic achieve-of-function mechanisms at equally the protein and the RNA https://naloxegoloxalate22109.bloguerosa.com/27765662/l-162-things-to-know-before-you-buy